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Download Cosmetics and Dermatology eBook PDF
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The Cosmetics and Dermatology eBook from Axol Bioscience showcases the next generation of in vitro models for skincare and cosmetic ingredient testing. Built on human iPSC technology, Axol’s models offer reproducible, scalable, and ethically sourced alternatives to primary cells and animal testing.
Key highlights include:
- iPSC-derived sebocytes: Express PPARγ, KRT7, MUC1; produce sebum; respond to testosterone and linoleic acid; ideal for acne and hyperseborrhea studies
- iPSC-derived melanocytes: Pigmented, dendritic cells from diverse donors (Caucasian, African, Asian, Albino); support tanning and lightening bioassays; express PAX3, MITF, PMEL17, TYRP1
- iPSC-derived sensory neurons: Express Nav1.7, Nav1.8, TRPV1, TRPA1; used in pain, itch, and neurocosmetic models; validated with capsaicin, menthol, and paclitaxel
- Validated endpoints: Lipid synthesis, cytokine release, pigmentation, cell viability, ATP levels, and inflammation profiling via RT-qPCR and ELISA
- Custom manufacturing & services: Scalable production of skin-relevant cell types; outsourced compound testing; 3D skin models and co-culture systems for neurocosmetics
The eBook also explores future directions in dermatology, including 3D skin reconstruction and sensory neuron co-culture models for mood and stress modulation via the skin.
Featured Axol Products:
- PCi-SEB-CAU / KIT: iPSC-derived sebocytes and media
- PCi-MEL-CAU / AFR / ASI / ALB / KIT: iPSC-derived melanocytes from diverse donors
- axoCells™ Sensory Neuron Kits (ax0055 / ax0555 / ax0157)