Axol Bioscience – iPSCs and New Approach Methodologies (NAMs)

The Axol Bioscience 2025 – iPSCs and Microphysiological Systems (MPS) Technology Journal is a curated collection of technical papers and collaborative studies demonstrating the power of Axol’s iPSC-derived cells in cutting-edge MPS platforms. This resource highlights how axoCells™ are enabling more predictive, human-relevant in vitro models across neuroscience, cardiology, and sensory biology.

Key highlights include:

• Cardiac Models: Chamber-specific atrial and ventricular cardiomyocytes used in heart-on-chip systems, MEA platforms, and SmartHeart® assays for drug screening and cardiotoxicity profiling.
• Neurodegenerative Disease Models: ALS motor neuron phenotyping using MEA and electrical imaging, including hyperexcitability and network burst analysis.
• Sensory Neuron Applications: Pathway profiling, neurotoxicity screening via deep learning, and bio-digital sensor development for PNS research.
• Microglia Assays: High-content imaging and multiplexed phagocytosis assays for neuroinflammation studies.
• Organ-on-Chip Innovations: 3D brain microtissues, neuromuscular junction modeling, and RealBrain® systems for Alzheimer’s research.

The journal also includes data from leading platforms such as Axion BioSystems, 3Brain, BiomimX, CytoTronics, NETRI, Mimetas, Ushio, and Sygnature Discovery, all powered by Axol’s axoCells™.

Featured Axol Products:

• axoCells™ Atrial & Ventricular Cardiomyocytes
• axoCells™ Microglia, Sensory Neurons, Motor Neurons